858-525-5007

643 Grand, South San Francisco CA 94080 | $1,248,000

  • 3 bedrooms
  • 4 bathrooms
  • 1,630 Sq Ft
  • 3500 Lot Sq Ft
  • Type: Single Family Residence
  • Stories: 2
  • Year Built: 1895
  • MLS#: ML82059314
  • Community: 699 - Not Defined

Listing provided courtesy of Jill Penna of Christie's International Real Estate Sereno. Last updated 2026-09-26 08:14:02.000000. Listing information © 2025 SANDICOR.

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging and an additional 2 car off street parking in front of the house. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

More Details

0.08 Acres
2 Stories

David Piper​

Call or Text: 858-525-5007

DRE# 02021985